Journal: Vaccines

Article Title: COVID-19 Vaccines: Current and Future Perspectives

doi: 10.3390/vaccines10040608

Figure Lengend Snippet: Main nanoparticles for COVID-19 vaccines.

Article Snippet: CVnCoV CureVac AG , Lipid nanoparticles containing ionizable lipid ALC-0315 , mRNA , RNA carrier for safe and efficient transport in vivo [ ] .

Techniques: Vaccines, In Vivo, Virus, Binding Assay

Journal: Signal Transduction and Targeted Therapy

Article Title: Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications

doi: 10.1038/s41392-024-02002-z

Figure Lengend Snippet: Representative completed and ongoing clinical studies (immunotherapy)

Article Snippet: , , mRNA-1345 , RSV , RSV prefusion stabilized F (preF) glycoprotein , LNPs (ionizable lipid, phospholipid, PEG lipid, sterol) , Intramuscular injection , 2023-10-06 , Phase III , Recruiting , / , NCT06067230 , ModernaTX, Inc. , .

Techniques: Virus, Injection, Membrane, Immunopeptidomics, Adjuvant, Activity Assay, Plasmid Preparation, Saline, Electroporation, Transfection, Inhibition

Journal: Signal Transduction and Targeted Therapy

Article Title: Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications

doi: 10.1038/s41392-024-02002-z

Figure Lengend Snippet: Representative completed and ongoing clinical studies (non-immunotherapy)

Article Snippet: , , mRNA-1345 , RSV , RSV prefusion stabilized F (preF) glycoprotein , LNPs (ionizable lipid, phospholipid, PEG lipid, sterol) , Intramuscular injection , 2023-10-06 , Phase III , Recruiting , / , NCT06067230 , ModernaTX, Inc. , .

Techniques: Injection, CRISPR, Zinc-Fingers

Journal: Signal Transduction and Targeted Therapy

Article Title: Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications

doi: 10.1038/s41392-024-02002-z

Figure Lengend Snippet: Representative preclinical studies (non-immunotherapy)

Article Snippet: , , mRNA-1345 , RSV , RSV prefusion stabilized F (preF) glycoprotein , LNPs (ionizable lipid, phospholipid, PEG lipid, sterol) , Intramuscular injection , 2023-10-06 , Phase III , Recruiting , / , NCT06067230 , ModernaTX, Inc. , .

Techniques: Coagulation, Injection, Polymer, Blocking Assay

Journal: Pharmaceutics

Article Title: Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach

doi: 10.3390/pharmaceutics17010102

Figure Lengend Snippet: Nanoparticle Delivery Systems in Relation to GA.

Article Snippet: 9 , Urate oxidase mRNA encapsulated in ionizable lipid nanocarriers (mUox@iLAND). , Ionizable lipid carriers loaded with dual nucleic acids: luciferase mRNA and fluorescent siRNA. Intravenously administered to HU mice. , Nanocarrier analysis revealed size ~169 nm, uniformity index 0.148, surface charge −1.22 mV, and mRNA loading of 94.2%. , iLAND internalization occurs via multiple routes: caveolae, clathrin-dependent endocytosis, macropinocytosis, and independent mechanisms. , The Nanocarrier system employs receptor-mediated internalization and endosomal release, providing sustained therapeutic effects. Unlike allopurinol’s acute response, mUox@iLAND achieved prolonged UA reduction through controlled delivery. , [ ] .

Techniques: Homogenization, Produced, Zeta Potential Analyzer, Encapsulation, In Vitro, Enzyme Inhibition Assay, Synthesized, Emulsion, Solvent, Evaporation, Solubility, Mouse Assay, Histopathology, Formulation, Diffusion-based Assay, Molecular Weight, Polymer, Concentration Assay, In Vivo, Activity Assay, Microscopy, Antioxidant Activity Assay, Membrane, Inhibition, Luciferase